TrialNet: Open Source Clinical Trials Powered by Aiken

[Proposal setup] Proposal title

Please provide your proposal title

TrialNet: Open Source Clinical Trials Powered by Aiken

[Proposal Summary] Budget Information

Enter the amount of funding you are requesting in ADA

68500

[Proposal Summary] Time

Please specify how many months you expect your project to last

8

[Proposal Summary] Translation Information

Please indicate if your proposal has been auto-translated

No

Original Language

en

[Proposal Summary] Problem Statement

What is the problem you want to solve?

Compromised clinical trial data, due to errors or manipulation, leads to unreliable results, undermining trust and delaying the approval of safe treatments, ultimately risking public health.

[Proposal Summary] Project Dependencies

Does your project have any dependencies on other organizations, technical or otherwise?

No

Describe any dependencies or write 'No dependencies'

No dependencies

[Proposal Summary] Project Open Source

Will your project's outputs be fully open source?

Yes

License and Additional Information

The outputs will be completly OPEN SOURCE, making the smart contracts and blockchain integration code available to the community. The code will be shared on GitHub under a permissive license (e.g., MIT or Apache 2.0), ensuring wide access and promoting innovation across the health sector. Additionally, documentation and developer guides will be provided to facilitate adoption and further development by the community.

[Theme Selection] Theme

Please choose the most relevant theme and tag related to the outcomes of your proposal.

Healthcare

[Campaign Category] Category Questions

Describe what makes your idea innovative compared to what has been previously funded (whether by you or others).

TrialNet will be an open-source, blockchain-based platform that secures clinical trial data, automates processes, and ensures transparency and compliance:

• Data Security: Cardano’s blockchain encrypts and protects patient information, preventing unauthorized access.
• Smart Contracts: Automates payments, data collection, and consent, reducing errors and boosting efficiency.
• Transparency: Every step, from consent to results, is traceable, building trust among stakeholders.

Describe what your prototype or MVP will demonstrate, and where it can be accessed.

It will demonstrates real-world impact in healthcare using Aiken’s smart contracts.

Expands Cardano’s Reach, Appling blockchain in a regulated, data-sensitive industry, boosting adoption.

A successful implementation enhances Cardano’s credibility and contributes to medical innovation.

Describe realistic measures of success, ideally with on-chain metrics.

TrialNet will demonstrate its impact through measurable KPIs and outcomes, proving its effectiveness in clinical trials:

• Pilot Trials Success: Collaborate with pharma companies to run secure, transparent pilot trials, showing faster completion rates and increased patient trust.
• User Adoption: Measure platform use among pharma companies, CROs, and researchers. High adoption and positive feedback confirm its value and relevance.

[Your Project and Solution] Solution

Please describe your proposed solution and how it addresses the problem

TrialNet protects patient data in clinical trials, addressing risks like breaches, inefficiencies, and lack of transparency. With Aiken smart contracts and NFTs, it helps ensure every participant’s information is secure, builds trust, and supports better health outcomes.

Key Features of TrialNet:

1. Secure Patient Data: TrialNet’s user-friendly interface securely manages sensitive patient information, storing it on Cardano’s blockchain with encryption and immutabilit
2. Clear Transparency and Trust: Every trial phase is recorded on the blockchain, offering patients, researchers, and regulators a clear, real-time view of the dat
3. Simplified Processes with Smart Contracts: TrialNet automates critical tasks like participant payments and milestone tracking, reducing the burden on clinical teams and ensuring patients are compensated promptl
4. Faster and More Cost-Effective Trials: By minimizing manual work and eliminating intermediaries, TrialNet speeds up the completion of clinical trials, reduces costs, and minimizes errors, ultimately leading to quicker access to safe, effective treatments for patient
5. Open Collaboration for Greater Impact: All Aiken smart contracts used in TrialNet are open source, inviting the Cardano and global scientific communities to collaborat

How you perceive the problem you are solving

The problem is the poor data management in clinical trials:

• Data Security: Sensitive patient information is vulnerable to breaches and manipulation, compromising privacy and trial integrity.
• Lack of Transparency: Limited visibility makes it hard for patients, researchers, and regulators to verify trial phases and data authenticity, leading to distrust.
• Inefficiencies: Manual processes cause delays, errors, and high costs, slowing down trials and complicating compliance

Your reasons for approaching it in the way that you have

• TrialNet's approach tackles real-world clinical trial challenges by integrating Aiken smart contracts to secure patient data, ensure compliance, and automate manual processes.
• Patient-Focused Solution: TrialNet uses NFTs for patient tracking and smart contracts for payments, prioritizing patient safety and building trust with all stakeholders, including researchers and regulators.
• Scalable and Efficient: Automating trials reduces costs and enhances efficiency, making the system scalable for larger studies. TrialNet aims to set a new standard for blockchain use in healthcare, ensuring a lasting impact.

Who will your project engage

TrialNet engages key stakeholders to enhance clinical trials:

• Pharma Companies and Biotech Firms: Secure trial management, compliance, and faster drug development.
• CROs: Automates management, ensures data security, and streamlines processes across trial sites.
• Researchers: Provides a secure platform for data sharing, boosting collaboration and integrity.
• Regulatory Bodies: Transparent, immutable data simplifies audits and accelerates approvals.
• Patients: Ensures privacy and trust with secure data and automated compensation via smart contracts.
• Developers: Open-source collaboration drives innovation in health and blockchain.

How you will demonstrate or prove your impact

TrialNet will demonstrate its impact through measurable KPIs and outcomes, proving its effectiveness in clinical trials:

• Pilot Trials Success: Collaborate with pharma companies to run secure, transparent pilot trials, showing faster completion rates and increased patient trust.
• User Adoption: Measure platform use among pharma companies, CROs, and researchers. High adoption and positive feedback confirm its value and relevance.

What Makes TrialNet Unique?

TrialNet is an open-source, blockchain-based platform that secures clinical trial data, automates processes, and ensures transparency and compliance:

• Data Security: Cardano’s blockchain encrypts and protects patient information, preventing unauthorized access.
• Smart Contracts: Automates payments, data collection, and consent, reducing errors and boosting efficiency.
• Transparency: Every step, from consent to results, is traceable, building trust among stakeholders.

Who Benefits?

• Pharma Companies & CROs: More efficient trial management, lower costs, and improved data integrity.
• Researchers: Secure and transparent data handling enhances collaboration and reliability.
• Patients: Secure data, control over information, and automated payments increase trust and engagement.
• Regulators: Verifiable audit trails simplify monitoring and compliance.

Why is TrialNet Important for Cardano?

• Showcases Cardano’s Strengths: Demonstrates real-world impact in healthcare using Aiken’s smart contracts.
• Expands Cardano’s Reach: Applies blockchain in a regulated, data-sensitive industry, boosting adoption.
• Global Healthcare Impact: Successful implementation enhances Cardano’s credibility and contributes to medical innovation.

[Your Project and Solution] Impact

Please define the positive impact your project will have on the wider Cardano community

TrialNet's Positive Impact on Cardano

• Driving Adoption in Healthcare: TrialNet showcases Cardano's secure, transparent solution for clinical trial data, encouraging healthcare institutions and pharma companies to adopt Cardano, strengthening its reputation in regulated industries.
• Ecosystem Growth: By integrating with other dApps on Cardano, TrialNet promotes innovation and collaboration, contributing to the network's growth and diversity.
• Building Trust in Cardano: TrialNet’s success demonstrates Cardano’s ability to manage complex, sensitive data securely, boosting confidence in its technology for enterprise solutions.
• Raising Global Visibility: Targeting healthcare globally, TrialNet increases awareness of Cardano’s scalable and secure solutions, enhancing network visibility.

Measuring Impact

Quantitative:

• Track clinical trials managed using TrialNet to show efficiency improvements.
• Measure the number of organizations using TrialNet to gauge adoption and growth.

Qualitative:

• Collect feedback from patients, researchers, and sponsors on ease of use, transparency, and security to assess user satisfaction.

Sharing Outputs and Opportunities

Open Source Contributions:

Publish code, smart contracts, and documentation on GitHub under an open-source license, allowing community collaboration and development.

Provide guides and tutorials for easy adoption.

Regular Updates:

Publish case studies and insights on platforms like Medium, LinkedIn, and Cardano blogs, highlighting TrialNet’s impact and opportunities for further integration.

Open Access to Results:

Share impact reports with the Cardano community and healthcare stakeholders, detailing trial results and feedback to showcase benefits and future opportunities.

[Your Project and Solution] Capabilities & Feasibility

What is your capability to deliver your project with high levels of trust and accountability? How do you intend to validate if your approach is feasible?

Our team combines scientific and blockchain expertise, making us highly qualified to execute this project successfully.

Leonardo Dandeu is a doctoral fellow at CONICET conducting research on the role of the tumor microbiome in early-stage breast cancer. With a strong background in transfusion medicine, molecular biology, and cancer biology, he has contributed to interdisciplinary projects bridging clinical and experimental research. Prior to his PhD, he worked as a hematology technician for over eight years and taught courses in immunohematology, demonstrating both technical expertise and academic leadership. Currently based at the Institute of Biology and Experimental Medicine (IBYME), Leonardo is advancing research at the intersection of microbiome science and oncology, aiming to uncover novel therapeutic insights.

https://www.linkedin.com/in/leonardo-dandeu-15ab33aa/

Damián Hryb, a respected engineer and active member of the Cardano community since 2021, is the founder of CardanoTrees, the first fully on-chain evolutive generative art project on Cardano, where digital trees grow autonomously—merging blockchain, visual art, and environmental awareness. He played a key role in Veritree’s Initial Tree Offering (ITO), a milestone collaboration with Cardano Forest that enabled the planting of real trees through blockchain innovation. Damián has been recognized in several Cardano hackathons, including winning first place at the Cardano Tech week hackathon and second place in the Cardano LATAM Builders Hackathon . He has extensive experience developing with Cardano, has completed the Smart Contract Programming course from ADALAB–UTN (organized by IOHK), and continues to advance his expertise using next-generation tools such as Aiken. Beyond blockchain, Damián brings over 15 years of experience as a university professor in Argentina, teaching engineering and numerical modeling, which enriches his ability to connect technology with education, creativity, and sustainable impact.

Together, we won second place in the Cardano LATAM Builders Hackathon, showcasing our technical competence with a project similar to our Fund 14 proposal. Our combined expertise in blockchain, scientific research, and project management ensures we can deliver this project with excellence. Supported by experts in data analysis, finance, and design, our team is equipped to guarantee trust, accountability, and innovation throughout the project lifecycle.

https://x.com/D_art_tech

https://www.linkedin.com/in/dami%C3%A1n-emmanuel-hryb-32834b29/

[Milestones] Project Milestones

Milestone Title

Smart Contract and DApp Design, Web & Social Media Setup

Milestone Outputs

• Research and design of smart contract models and DApp architecture.
• Development of a TrialNet website to present the project, its functionalities, and its roadmap.
• Creation of social media accounts (Twitter, LinkedIn, etc.) to communicate project updates to the community and attract future collaborators and institutions.

Acceptance Criteria

• Detailed technical document of the smart contract and its implementation in Aiken.
• TrialNet website published and accessible, with detailed project information and its functionalities.
• Social media accounts created and active, with an initial communication strategy focused on sharing project progress and key milestones.

Evidence of Completion

• Published technical document detailing the smart contract design and DApp architecture.
• Website up and running, showcasing relevant project information.
• Active social media accounts with at least two initial posts sharing project status and goals.

Delivery Month

2

Cost

18000

Progress

30 %

Milestone Title

Front-End Implementation, Smart Contract Integration, and Pilot Project Selection

Milestone Outputs

• Development of a fully functional smart contract in Aiken.
• Development of a simple front-end and smart contract integration, enabling the management of clinical trials directly through the DApp.
• Creation of a form to select companies or scientific research projects to make a pilot project.
• Selection process for projects via a form, evaluation of proposals, and announcement of the selected projects for implementation.

Acceptance Criteria

• Operational front-end connected to the smart contract, enabling clinical trial management.
• Publication of the smart contract for the community, with clear documentation on its usage.
• Creation of a form and launch of the call for companies or research projects to be selected.
• Selection of at least one project for the free implementation of the smart contract.

Evidence of Completion

• Link to Operational DApp with a front-end connected to the smart contract and ready for use.
• Link to Official publication of the smart contract along with user documentation for the community.
• Link to Form created and selection process completed, with public announcement of the selected projects.

Delivery Month

5

Cost

25000

Progress

60 %

Milestone Title

Adaptation to Selected Project and Scientific Article Creation

Milestone Outputs

• Adaptation of the smart contract to the specific requirements of the selected project.
• Implementation of the adapted smart contract for the selected project, allowing the management of clinical trials.
• Collection of user feedback on the DApp and smart contract, focusing on usability, efficiency, and the security of clinical data management.
• Creation of a scientific article detailing the technological advancements, the implementation of the smart contract, and the feedback received, for publication in the scientific and blockchain communities.

Acceptance Criteria

• Successful adaptation of the smart contract for the selected project and its functional implementation.
• Collection of positive feedback from at least 70% of the users.
• Scientific article written and ready for publication, with a comprehensive analysis of the project’s results.

Evidence of Completion

• Adapted smart contract in use by the selected project.
• Feedback report with analysis of improvements and suggestions for future versions.
• Scientific article published or ready for submission to a specialized journal or platform.

Delivery Month

7

Cost

18000

Progress

90 %

Milestone Title

Final Summary and Reporting

Milestone Outputs

• Final document summarizing the entire process, from smart contract development to its implementation and adaptation for clinical trials.
• Creation of a summary video showcasing the development process, implementation, and results achieved with TrialNet, highlighting its impact on clinical trial management.

Acceptance Criteria

• Final document delivered to the Catalyst community with a complete summary of the project and its outcomes.
• Published summary video, accessible to the community, showcasing the achievements during the 7-month project execution.

Evidence of Completion

• Link to the final document on the Catalyst platform.
• Summary video available to the Catalyst community.

Delivery Month

8

Cost

7500

Progress

100 %

[Final Pitch] Budget & Costs

Please provide a cost breakdown of the proposed work and resources

Milestone 1 - 2 months

14000 ADA - Research and design of smart contract models and DApp architecture.

2500 ADA - Creation of website and social media channels.

1500 ADA - Project management.

Milestone 2 - 3 months

21000 ADA - Development of a fully functional smart contract. Creation of a simple front-end interface to interact with the smart contract.

2500 ADA - Launch of the call for companies or research projects to make a pilot project. Evaluation of proposals and selection of at least one project.

1500 ADA - Project management.

Milestone 3 - 2 months

14000 ADA - Adaptation and customization of the DApp for use by the selected project in a pilot project.

2500 ADA - Writing and submission of a scientific document on the use of Cardano for clinical trials.

1500 ADA - Project management.

Final Milestone - 1 month

3500 ADA - Final document summarizing the entire process, from smart contract development to its implementation, adaptation for a partner company and pilot project results.

2500 ADA - Summary video.

1500 ADA - Project management.

Total 68500 ADA

[Final Pitch] Value for Money

How does the cost of the project represent value for the Cardano ecosystem?

68500 ADA over 8 months is just 8500 ADA per month—an investment that showcases Cardano’s blockchain capabilities to the DeSci community. This project will develop a smart contract using Aiken, a DApp, and NFTs for clinical trial data security, demonstrating Cardano's real-world impact in health and research.

By engaging scientific institutions and pharmaceutical companies, we’ll show the efficiency, security, and transparency that Cardano offers, encouraging adoption. An open-source release and scientific publication will position Cardano as a leader in decentralized science and health innovation.

With our skilled team and clear roadmap, this project promises long-term benefits, expanding Cardano’s user base and utility in the scientific community. It’s a strategic investment to boost adoption, visibility, and trust within the DeSci ecosystem.

[Required Acknowledgements] Consent & Confirmation

Terms and Conditions:

Yes